However, many multilateral agreements, which are not health and environmentally motivated or focused on, have a significant impact on both. For example, the Environment Directorate of the Organisation for Economic Co-operation and Development (OECD) has an environment and health office and has proven to be the driving force behind the use of coherent environmental policies in all Member States. Among his first articles was the establishment of an independent scientific monitoring of the drivers of acid rain and the fate and transport of the pollutants that cause it. The OECD establishes global environmental assessments of countries by Member States, which include an environmental performance assessment, which promote transparency and can lead to changes in policies and processes. They also set mandatory testing standards for many toxins used in commercial products. The number of bilateral investment agreements increased rapidly during the 1990s. countries and investors are inspired by increased security regulation, security and mobility of their investments, after it became clear that the Uruguay Round Trade Investment Measures (TRIMS) Agreement, the Trade-Related Intellectual Property Rights (ADPIC) Agreement and the General Trade in Services Agreement (GATS) only took into account some of the investment-related concerns and that investors were not sufficient security and strong controls by multinationals.  In addition to these instruments, the World Bank adopted guidelines in 1992 for the treatment of foreign direct investment.  In 1994, the Energy Charter Treaty set an example of a multilateral investment agreement, but limited to the energy sector. The MAI has attracted widespread criticism, particularly from non-governmental workers` and environmentalists, which has led to numerous demonstrations and protests around the world. In countries such as Canada and France, the MAI has been seen as a threat to local cultures and national sovereignty. This finally led, in 1998, to France`s withdrawal from the MAI negotiations.
After France`s withdrawal, many countries followed and the draft treaty was rejected in 1999. Today, the TRIM agreement remains the most important legal framework within the WTO for the EU directly at the multilateral level. Asia Pacific Partnership (APP) for Clean Development and Climate was founded in July 2005. Aspects of Taplin and McGee`s (2010) discussion on the development and implications of the APP are repeated here. The APP is a multilateral agreement between Australia, Canada, China, India, Japan, the Republic of Korea (Korea) and the United States.